The research aims to explore about what patients with HIV-infection have in mind by consuming controlled antiretrovirals about their medication. This research placed in Care, Supportive and Treatment (CST) clinic on KRT Setjonegoro Regional Public Hospital, Wonosobo, Indonesia. The sampling of research used cross-sectional method through March-April 2019. We used an instrument adopted by an anonymous questionnaire. A total of 62 participants involved in this study. The result of research showed that although the patients consistently undergoing antiretrovirals therapy, there is also a bunch of miserable risks and threats on their minds. The awareness of undergoing therapy does not directly reflect a complete understanding of antiretrovirals