The objective of this study is to explain the impact of the Web 2.0 on student learning at Universidad Autónoma de San Luis Potosí Middle Zone Multidisciplinary Academic Unit (UAMZM), based on students’ perceptions of teachers’ attitudes, training, and use of the Web 2.0. The study adopted a cross- sectional cause-effect design, using probabilistic sampling by clusters of the seven-degree programs offered at the university, for a total of 207 respondents. Multiple regression analysis was performed. The results show that use and training are the variables that best explain the impact of the Web on the teaching-learning process