Systemic lupus erythematosus (SLE) is a heterogeneous, autoimmune disease, with internal organ injury, which can lead to severe morbidity and mortality. The study included 25 SLE, where their age ranged from 20 to 52 years and the duration of disease ranged from 1 to 30 years. The point of the present investigation was to assess relation cardiovesicular disease and systemic lupus erythromatosus using different biomarker (cholesterol, triglycerides, IL-8, LDH, CK and cTnI), and decide the recurrence of some atherosclerosis biomarkers in SLE patients with and without CVD contrasted to controls group. The results showed that the levels of cholesterol, triglycerides in the SLE patient group were significantly elevated (158.30±4.989 mg/dl and 114.65±14.221mg/dl) compared to healthy control (129.43±5.025mg/dl and 68.91±2.343mg/dl). As well as higher level of IL-8 a significant raised (60.366±9.667) in patient with sle than control group (8.245±0.539) and the IL-8 level was correlated to disease activity. However, no significant difference of IL-8 level with gender, residence, age and duration of disease. Moreover, there was a significant elevated in LDH, CK and cTnI levels (8.839±0.465, 6.661±0.628 and 0.206±0.011) in SLE patients than control group (7.778±0.280, 5.248±0.352 and 0.180±0.008). Conclusions: Abnormal myocardial biomarkers and lipid profiles may be lead to premature atherosclerosis, hence cardiovascular associated with SLE patients and assessment lupus erythematosus as a hazard factor for cardiovascular disease