In Hai Phong – Quang Ninh seaports, the volume of hazardous and noxious substances has been increased rapidly in recent years along with the speed of industrialization in the North of Vietnam. Environmental protection, prevention and response to incidents with hazardous and noxious substances at these above seaport areas faced drawbacks such as poor infrastructure, lack of human resources and specialized guidance, inappropriate management models and limited financial resources. Therefore, this research proposed technical and management solutions in order to improve the effectiveness of environmental protection, prevention and response to environmental incidents during loading-unloading and storing hazardous and noxious substances at seaports. Based on the survey and assessment process at some typical seaports, using SWOT tool and referring to related documents and researches which authors evaluated the environmental protection, prevention and response with incidents during loading- unloading and storing hazardous and noxious substances at Haiphong and Quangninh seaports and proposed the management solutions such as: establishment a state management organization model for seaports; issuing technical regulations; strengthening human resources, finance and international cooperation; technical solutions including infrastructural improvements, incident prevention plan and applying ISO standards