In the Vivo of corrosion of the cobalt-chromium-molybdenum defined by (CoCrMo) alloy and its prospective opposing effect on the body are recognized as a critical concern regarding using as a biomaterial for biomedical applications for years. The underlying mechanism of the mechanical and general assisted corrosion (MAC) associated with some biomedical applications, such as orthopedic implants, are extensively studied and documented. These studies are focused on the effect of wear particles and ions of metal on the biological response. However, some researches have been reported some inflammatory issues due to metal corrosion used for CoCrMo implants. This challenge has to change the way of understanding the relationship between corrosion and biological system, which is called ―corrosion causes biological responses‖. This article introduces a brief review on the Vivo corrosion of implants manufactured from CoCrMo. The major part will be focusing on the inflammatory cell-induced corrosion (ICIC) and the new viewpoint about the 2-way feedback loop between the human body and corrosion. Recent recovery researches on ICIC and its clinical importance are going to be explained. The species of reactive chemicals, biological elements, and electrochemistry associated with the ICIC underlying mechanism are going to be shown as well.